For example, the model amoeba Dictyostelium discodium is single celled under conditions of nutritional abundance, but upon starvation, it communicates to form aggregates that subsequently pass through multicellular stages of slug and fruiting body. Indeed, in light of recent discoveries of communication among bacteria and the importance and prevalence of bacterial biofilms, “single celled” may turn out to be a misnomer even for these organisms. Here we highlight some of the better studied examples of cooperation among microorganisms and attempt to identify some of the important questions in this emerging field.
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